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10 Best acetaminophens of 2025

Save up to 24% off
  • Best Choice

    1

    Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
    Amazon Basic Care

    Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

    9.7
    Exceptional
    Our Rating
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  • Value for Money

    2

    Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
    Amazon Basic Care

    Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

    9.5
    Excellent

  • 3

    Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis
    TIME-CAP LABS, INC.

    Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

    9.4
    Excellent

  • 4

    GenCare - Acetaminophen 500mg Extra Strength Pain Relief (300 Caplets) - Multi Symptom Pain Reliever for Headache, Sinus, Arthritis, Back Pain Muscle Ache, Toothache, Fever Reducer, Migraine
    GenCare

    GenCare - Acetaminophen 500mg Extra Strength Pain Relief (300 Caplets) - Multi Symptom Pain Reliever for Headache, Sinus, Arthritis, Back Pain Muscle Ache, Toothache, Fever Reducer, Migraine

    9.3
    Excellent

  • 5

    HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))
    HealthA2Z

    HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

    9.2
    Excellent
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  • 6

    Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine
    Tylenol

    Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

    24% Off
    9.1
    Excellent
    Our Rating

  • 7

    GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
    GoodSense

    GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

    9.0
    Excellent
    Our Rating

  • 8

    Amazon Basic Care - Extra Strength Acetaminophen Caplet 500 mg, 100 Count ( 50 pouches of 2 caplets )
    Amazon Basic Care

    Amazon Basic Care - Extra Strength Acetaminophen Caplet 500 mg, 100 Count ( 50 pouches of 2 caplets )

    8.8
    Very Good

  • 9

    Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary
    Amazon Basic Care

    Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary

    8.5
    Good
    Our Rating

  • 10

    Genexa Clean Acetaminophen 500mg Extra Strength, Dye Free Pain Reliever Fever Reducer, 0% Artificial Additives, Pain Medicine for Adults, Relieves Headache, Backache, Minor Arthritis Pain, 100 Tablets
    Genexa

    Genexa Clean Acetaminophen 500mg Extra Strength, Dye Free Pain Reliever Fever Reducer, 0% Artificial Additives, Pain Medicine for Adults, Relieves Headache, Backache, Minor Arthritis Pain, 100 Tablets

    8.4
    Good