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10 Best pain relievers of 2025

Save up to 24% off
  • Best Choice

    1

    Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
    Amazon Basic Care

    Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

    9.8
    Exceptional
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  • Value for Money

    2

    Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count
    Advil

    Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count

    9.5
    Excellent
    Our Rating

  • 3

    Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)
    Amazon Basic Care

    Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

    9.4
    Excellent
    Our Rating

  • 4

    Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct
    Tylenol

    Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

    24% Off
    9.3
    Excellent
    Our Rating

  • 5

    Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets
    Advil

    Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets

    11% Off
    9.1
    Excellent
    Our Rating
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  • 6

    Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets
    Advil

    Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets

    8.9
    Very Good
    Our Rating

  • 7

    Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count
    Tylenol

    Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count

    8.8
    Very Good
    Our Rating

  • 8

    GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
    GoodSense

    GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

    8.7
    Very Good
    Our Rating

  • 9

    Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)
    Amazon Basic Care

    Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

    8.6
    Very Good
    Our Rating

  • 10

    Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, FSA or HSA Eligible, 100 ct
    Tylenol

    Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, FSA or HSA Eligible, 100 ct

    8.3
    Good
    Our Rating