Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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10 Best pain relievers of 2025
Save up to 24% off
Best Choice1
Amazon Basic CareAmazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
9.8Exceptional
Our Rating
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Value for Money2
A+HealthA+Health Ibuprofen 200 Mg Softgels, Pain Reliever/Fever Reducer (NSAID), 300 Count
9.7Exceptional
Our Rating
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3
Amazon Basic CareAmazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)
9.6Exceptional
Our Rating
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4
TylenolTylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine
24% Off9.5Excellent
Our Rating
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5
TylenolTylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, 100 ct
9.4Excellent
Our Rating
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Amazon Basic CareAmazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)
22% Off9.3Excellent
Our Rating
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7
Amazon Basic CareAmazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache, Arthritis and More, Brown, 200 Count (Packaging may vary)
9.1Excellent
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8
TylenolTylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle
9.0Excellent
Our Rating
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9
A+HealthA+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets, 216 Count
8.8Very Good
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10
Amazon Basic CareAmazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache, Arthritis and More, 1000 Count (Packaging may vary)
8.6Very Good
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